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NBS-C BioScience
Biacore SPR Technology is Applied in a Variety of R&D Projects
Life Science - Research Applications:
- Determine expression levels of selected proteins under different conditions
- Identify binding partners to any target molecule - ligand fishing
- Elucidate the function of novel proteins in proteomics research
- Find antagonists to critical binding events
- Investigate the binding properties of protein isoforms
- Identify disease markers in clinical samples
- Optimize therapeutic antibodies
- Unravel the intricate molecular interactions involved in cell signaling pathways
- Evaluate ion selectivity in signaling pathways
- Determine the nature of protein complexes and their function
- Study membrane associated molecules in near native environments
- Identify DNA damage - mutations, DNA adducts etc.
Drug Discovery and Development Applications:
- Proteomics - target identification and ligand fishing
- Target assay validation for High Throughput Screening (HTS)
- 'Hit' to lead characterization - rapid affinity ranking and detailed kinetics of interaction for small molecules binding to target proteins
- Lead optimization through interaction kinetic based QSAR (Quantitative Structure Activity Relationship
- Early ADME (Absorption, Distribution, Metabolism, Excretion) - rapid in vitro assays for defined ADME parameters, such as protein binding studies
- Clinical trials - stratification of patient response to therapeutics
- Immunogenicity assessment - determination and characterization of anti-drug antibody (ADA) responses of biotherapeutics
- Vaccine development - quantification and characterization of the immune response induced by preventive and therapeutic vaccines
- Production and manufacturing - process and batch QC of therapeutic antibodies and proteins