NBS-C BioScience
Novel aryl sulfonamide derivatives as NLRP3 inflammasome inhibitors for the potential treatment of cancer.
Albanese V, Missiroli S, Perrone M, Fabbri M, Boncompagni C, Pacifico S, De Ventura T, Ciancetta A, Dondio G, Kricek F, Pinton P, Guerrini R, Preti D, Giorgi C.
J. Med. Chem 2023, March 27; 66, 7: 5223-5241
A Small Contribution to a Large System: The Leptin Receptor Complex.
Jennifer M Simien, Grace E Orellana, Hoa T N Phan, Yao Hu, Emily A Kurth, Christine Ruf, Franz Kricek, Qian Wang, Alan V Smrcka, Ellinor Haglund
Journal of Physical Chemistry. B 2023 March 14
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment.
Missiroli S, Perrone M, Gafà R, Nicoli F, Bonora M, Morciano G, Boncompagni C, Marchi S, Lebiedzinska-Arciszewska M, Vezzani B, Lanza G, Kricek F, Borghi A, Fiorica F, Ito K, Wieckowski M, Di Virgilio F, Abelli L, Pinton P. Giorgi C.
Cell Death Differ. 2023 Feb;30(2):429-441
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.
Monteil V, Eaton B, Postnikova E, Murphy M, Braunsfeld B, Crozier I, Kricek F, Niederhöfer J, Schwarzböck A, Breid H, Devignot S, Klingström J, Thålin C, Kellner MJ, Christ W, Havervall S, Mereiter S, Knapp S, Sanchez Jimenez A, Bugajska-Schretter A, Dohnal A, Ruf C, Gugenberger R, Hagelkruys A, Montserrat N, Kozieradzki I, Hasan Ali O, Stadlmann J, Holbrook MR, Schmaljohn C, Oostenbrink C, Shoemaker RH, Mirazimi A, Wirnsberger G, Penninger JM.
EMBO Mol Med. 2022 Aug 8;14(8):e15230. doi: 10
BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos.
Novelli F, Bononi A, Wang Q, Bai F, Patergnani S, Kricek F, Haglund E, Suarez JS, Tanji M, Xu R, Takanishi Y, Minaai M, Pastorino S, Morris P, Sakamoto G, Pass HI, Barbour H, Gaudino G, Giorgi C, Pinton P, Onuchic JN, Yang H, Carbone M. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2111946118.
The Peptide TAT-I24 with Antiviral Activity against DNA Viruses Binds Double-Stranded DNA with High Affinity.
Harant H, Höfinger S, Kricek F, Ruf C , Ruzsics Z, Hengel H, Lindley I.
Biologics 2021, 1(1), 41-60
IgE - directed approaches: A general strategy for the treatment of atopic diseases.
Kricek F.
In: Progress in Respiratory Research, Vol. 39: New Drugs and Targets for Asthma and COPD. T. Hansel and P. Barnes eds.
2010, p.49-53.
Trimolecular complex formation of IgE, FceRI, and a recombinant nonanaphylactic single-chain antibody fragment with high affinity for IgE. Lupinek C, Roux KH, Laffer S, Rauter I, Reginald K, Kneidinger M, Blatt K, Ball T, Pree I, Jahn-Schmid B, Allam JP, Novak N, Drescher A, Kricek F, Valent P, Englund H, Valenta R.
J Immunol. 2009 Apr 15;182(8):4817-29.
A high-affinity monoclonal anti-IgE antibody for depletion of IgE and IgE-bearing cells.
Laffer S, Lupinek C, Rauter I, Kneidinger M, Drescher A, Jordan JH, Krauth MT, Valent P, Kricek F, Spitzauer S, Englund H, Valenta R.
Allergy. 2008 Jun;63(6):695-702. Epub 2008 Mar 5.
Mast cell-derived proteases control allergic inflammation through cleavage of IgE.
Rauter I, Krauth MT, Westritschnig K, Horak F, Flicker S, Gieras A, Repa A, Balic N, Spitzauer S, Huss-Marp J, Brockow K, Darsow U, Behrendt H, Ring J, Kricek F, Valent P, Valenta R.
J Allergy Clin Immunol. 2008 Jan;121(1):197-202. Epub 2007 Sep 29.
Designed ankyrin repeat proteins as anti-idiotypic-binding molecules.
Vogel M, Keller-Gautschi E, Baumann MJ, Amstutz P, Ruf C, Kricek F, Stadler BM.
In: Autoimmunity, Part A: Basic Principles and New Diagnostic Tools. M. Gershwin and Y. Schoenfeld eds.
2007, chapter 2.
Conformationally constrained mimics of the membrane-proximal domain of FceRIa.
Peters C, Bacher M, Buenemann CL, Kricek F, Rondeau JM, Weigand K.
Chembiochem. 2007 Oct 15;8(15):1785-9.
EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells.
Kettner S, Kalthoff F, Graf P, Priller E, Kricek F, Lindley I, Schweighoffer T.
Mol Cell Biol. 2007 Nov;27(21):7718-26. Epub 2007 Sep 4.
Designed ankyrin repeat proteins as anti-idiotypic-binding molecules.
Vogel M, Keller-Gautschi E, Baumann MJ, Amstutz P, Ruf C, Kricek F, Stadler BM.
Ann N Y Acad Sci. 2007 Aug;1109:9-18.
Inhibition of human cord blood-derived mast cell responses by anti-FceRI mAb 15/1 versus anti-IgE Omalizumab.
Mirkina I, Schweighoffer T, Kricek F.
Immunol Lett. 2007 Apr 15;109(2):120-8. Epub 2007 Mar 1.
Poor association between allergen-specific serum immunoglobulin E levels, skin sensitivity and basophil degranulation: a study with recombinant birch pollen allergen Bet v 1 and an immunoglobulin E detection system measuring immunoglobulin E capable of binding to FceRI.
Purohit A, Laffer S, Metz-Favre C, Verot A, Kricek F, Valenta R, Pauli G.
Clin Exp Allergy. 2005 Feb;35(2):186-92.
A molecular model of type I allergy: identification and characterization of a nonanaphylactic anti-human IgE antibody fragment that blocks the IgE-FceRI interaction and reacts with receptor-bound IgE.
Laffer S, Hogbom E, Roux KH, Sperr WR, Valent P, Bankl HC, Vangelista L, Kricek F, Kraft D, Grönlund H, Valenta R.
J Allergy Clin Immunol. 2001 Sep;108(3):409-16.
Mapping the epitope of the anti-FceRIa mAb15/1 to peptide eRI.
Nechansky A, Kricek F.
Allergy. 2001 May;56(5):450.
Inhibition of antigen-induced mediator release from IgE-sensitized cells by a monoclonal anti-FceRI a-chain receptor antibody: implications for the involvement of the membrane-proximal a-chain region in FceRI-mediated cell activation.
Nechansky A, Robertson MW, Albrecht BA, Apgar JR, Kricek F.
J Immunol. 2001 May 15;166(10):5979-90.
Allergic manifestations as the results of a conditional autoimmune response.
Stadler BM, Miescher S, Horn M, Pachlopnik J, Stadler M, Kricek F, Vogel M.
Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):411-3.
Effects of complement inactivation and IgG depletion on skin reactivity to autologous serum in chronic idiopathic urticaria.
Fagiolo U, Kricek F, Ruf C, Peserico A, Amadori A, Cancian M.
J Allergy Clin Immunol. 2000 Sep;106(3):567-72.
Molecular basis for nonanaphylactogenicity of a monoclonal anti-IgE antibody.
Rudolf MP, Zuercher AW, Nechansky A, Ruf C, Vogel M, Miescher SM, Stadler BM, Kricek F.
J Immunol. 2000 Jul 15;165(2):813-9.
Mimicry of human IgE epitopes by anti-idiotypic antibodies.
Vogel M, Miescher S, Kuhn S, Zürcher AW, Stadler MB, Ruf C, Effenberger F, Kricek F, Stadler BM.
J Mol Biol. 2000 May 19;298(5):729-35.
Interaction of human IgE with FceRIa exposes hidden epitopes on IgE.
Nechansky A, Ruf C, Pursch E, Wasserbauer E, Stämpfli MR, Pachlopnik JM, Stadler BM, Kricek F.
Int Arch Allergy Immunol. 1999 Dec;120(4):295-302.
Human anti-FceRIa autoantibodies isolated from healthy donors cross-react with tetanus toxoid.
Horn MP, Gerster T, Ochensberger B, Derer T, Kricek F, Jouvin MH, Kinet JP, Tschernig T, Vogel M, Stadler BM, Miescher SM.
Eur J Immunol. 1999 Apr;29(4):1139-48.
IgE-related peptide mimotopes. Basic structures for anti-allergy vaccine development.
Kricek F, Ruf C, Rudolf MP, Effenberger F, Mayer P, Stadler BM.
Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):222-3. No abstract available.
Mimotope and anti-idiotypic vaccines to induce an anti-IgE response.
Stadler BM, Zürcher AW, Miescher S, Kricek F, Vogel M.
Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):119-21.
An in vitro model for the allergen-IgE-FceRI interaction.
Laffer S, Hogbom E, Adrianson J, Grönlund H, Sillaber C, Valent P, Vangelista L, Kricek F, Kraft D, Valenta R.
Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):116-8.
The membrane-proximal part of FceRIa contributes to human IgE and antibody binding--implications for a general structural motif in Fc receptors.
Nechansky A, Aschauer H, Kricek F.
FEBS Lett. 1998 Dec 18;441(2):225-30.
Antigen interaction and heat inactivation expose new epitopes on human IgE.
Pachlopnik JM, Stämpfli MR, Rudolf MP, Aebischer I, Kricek F, Miescher S, Stadler BM.
Int Arch Allergy Immunol. 1998 Dec;117(4):231-8.
Epitope-specific antibody response to IgE by mimotope immunization.
Rudolf MP, Vogel M, Kricek F, Ruf C, Zürcher AW, Reuschel R, Auer M, Miescher S, Stadler BM.
J Immunol. 1998 Apr 1;160(7):3315-21.
Characterization of monoclonal antibodies directed against the a-subunit of the human IgE high-affinity receptor.
Nechansky A, Pursch E, Effenberger F, Kricek F.
Hybridoma. 1997 Oct;16(5):441-6.
Can active immunization redirect an anti-IgE immune response?
Stadler BM, Rudolf MP, Vogel M, Miescher S, Zürcher AW, Kricek F.
Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):216-8.
Suppression of in vivo IgE and tissue IL-4 mRNA induction by SDZ 280.636, a synthetic muramyl dipeptide derivative.
Kricek F, Zunic M, Ruf C, De Jong G, Dukor P, Bahr GM.
Immunopharmacology. 1997 Apr;36(1):27-39.
Effect of anti-IgE antibodies on FceRI-bound IgE.
Rudolf MP, Furukawa K, Miescher S, Vogel M, Kricek F, Stadler BM.
J Immunol. 1996 Dec 15;157(12):5646-52.
Oral administration of muramyl dipeptide into mice modulates cell proliferation, immunoglobulin synthesis and cytokine mRNA levels in gut associated lymphoid tissues.
Zunic M, Kricek F, Dukor P, Bahr GM.
Int J Immunopharmacol. 1996 Feb;18(2):155-62.
Induction in mice of serum IgE levels after treatment with anti-mouse IgD antibodies is preceded by differential modulation of tissue cytokine gene transcription.
Kricek F, Ruf C, Zunic M, De Jong G, Dukor P, Bahr GM.
Eur J Immunol. 1995 Apr;25(4):936-41.
Domain-specific anti-IgE antibodies interfere with IgE binding to FceRII.
Miescher S, Vogel M, Stämpfli MR, Wasserbauer E, Kricek F, Vorburger S, Stadler BM.
Int Arch Allergy Immunol. 1994 Sep;105(1):75-82.
Genomic structure of NKG5, a human NK and T cell-specific activation gene.
Houchins JP, Kricek F, Chujor CS, Heise CP, Yabe T, McSherry C, Bach FH.
Immunogenetics. 1993;37(2):102-7.
Hybrid genes expressing fusion peptides. A strategy for bacterial production of recombinant human interleukin-3 with a defined NH2-terminus.
Kricek F, Ruf C, Aschauer H, Stuchlik P, Graf C, Seifert JM, Werner FJ, Ehn G.
Ann N Y Acad Sci. 1991 Dec 27;646:136-9. No abstract available.
Recombinant murine granulocyte-macrophage colony-stimulating factor augments neutrophil recovery and enhances resistance to infections in myelosuppressed mice.
Mayer P, Schütze E, Lam C, Kricek F, Liehl E.
J Infect Dis. 1991 Mar;163(3):584-90.
Cloning the origin of transfer region of the resistance plasmid R1.
Ostermann E, Kricek F, Högenauer G. EMBO J. 1984 Aug;3(8):1731-5.